Apoquel Safety

The safety profile of Apoquel is supported by pharmacovigilance data over 5 years that showed adverse reactions were rare* and consistent with pivotal safety and efficacy studies

The most commonly reported adverse events were very rare* and in decreasing order were: vomiting, diarrhea, lethargy, anorexia, and blood-work changes. Less than 1 dog out of 10,000 treated experienced the most common individual adverse reactions.

Rare is defined as more than 1 but less than 10 dogs reacting per 10,000 dogs treated; very rare is defined as less than 1 dog reacting per 10,000 dogs treated.2 Reported incidence rate (calculated) is an estimated rate. Includes all adverse reactions regardless of whether the product was administered per label directions, concomitantly or if a potential causal relationship existed.1

Safe to use in dogs 12 months of age and older

Short-term side effects in a clinical trial

Most common side effects in a short-term clinical trial included vomiting and diarrhea3

Short-term side effects in a clinical trial

Most common side effects in a short-term clinical trial included vomiting and diarrhea3

Not for use in dogs with serious infections or for use in breeding, pregnant or lactating dogs

Can be used concomitantly with many medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), anti-infectives, parasiticides, antifungals and allergen-specific immunotherapy4

The use of Apoquel has not been evaluated in combination with other systemic immunosuppressants, such as corticosteroids and cyclosporines

Study Results

Adverse events from 2 studies: vs placebo and prednisolone in dogs with allergic dermatitis

Adverse events from 2 studies: vs placebo and Atopica® in dogs with atopic dermatitis

Cytopoint Indications

Cytopoint has been shown to be effective for the treatment of dogs against allergic dermatitis and atopic dermatitis.

Apoquel and Apoquel Chewable Indications

Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

Apoquel and Apoquel Chewable Important Safety Information

Do not use Apoquel or Apoquel Chewable in dogs less than 12 months of age or those with serious infections. Apoquel and Apoquel Chewable may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. Apoquel Chewable and Apoquel for dogs have not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel and Apoquel Chewable have been used safely with many common medications including parasiticides, antibiotics and vaccines.

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